Many of the scenes are filmed on location in the actual cell that housed John Wayne Gacy.

The filming location, the old Joliet Prison, actually only has cells stacked two high. To be able to show the cells stacked three high, a studio set was constructed.

Stacy Keach (the Prison Warden) spent six months in a British prison and modeled his character after the man in charge at that institution.

The character of "D.B. Cooper" is based on an actual person, who in 1971, after hijacking an airliner, extorted $200,000 from its owner, Northwest Orient, and leaped off the airborne plane with 21 pounds of $20 bills strapped to his body. He was never caught.

The 4-month hiatus between the airing of episodes 13 and 14 came back to haunt the producers. Lincoln's execution was scheduled to take place in May. All of a sudden it was snowing.

Robert Knepper (T-Bag) says he based the haircut of his character on an old Science teacher he had, who had a "poofy bit", which always stuck up at the front.

The name of the prison in the show, Fox River, shares the name of a river that runs through Western Chicagoland, near the real prison filming location.

Thirteen episodes had originally been ordered but due to the success of the show, Fox extended it to a full season.

According to an interview with Rockmond Dunbar the character of C-Note was only suppose to appear in the first 2 episodes but when the show was renewed for a full season C-Note's role was extended to a recurring character.

The electric chair is not used as a primary instrument of execution in the State of Illinois where the series is set. Originally, the method of execution scripted for Lincoln's death was via lethal injection. For shock value, however, this was changed to the electric chair. The State of Illinois currently has a moratorium on the death penalty.

Wentworth Miller was a last minute casting choice. He started filming about a week after auditioning/being cast.

Silas Weir Mitchell (Haywire) originally auditioned for the role of T-Bag.

STARRING:
Dominic Purcell as Lincoln Burrows
Wentworth Miller as Michael Scofield
Robin Tunney as Veronica Donovan
Amaury Nolasco as Sucre
Wade Williams as Bellick
Marshall Allman as LJ
Paul Adelstein as Agent Kellerman
Robert Knepper as T-Bag
Sarah Wayne Callies as Dr. Tancredi
Peter Stormare as Abruzzi
Stacey Keach as Henry Pope
Rockmond Dunbar as C-Note